Rueffer M, Zenk M H
Lehrstuhl für Pharmazeutische Biologie, Ludwig-Maximilians-Universität München, Munich, Germany.
FEBS Lett. 1998 Oct 30;438(1-2):111-3. doi: 10.1016/s0014-5793(98)01282-4.
Microsomal preparations from immature seeds of Colchicum autumnale L. catalyse the ring expansion reaction of O-methylandrocymbine to demecolcine in the presence of NADPH and O2. In addition evidence is given for further transformation of demecolcine to colchicine in the presence of acetyl-CoA and NADPH.
秋水仙（Colchicum autumnale L.）未成熟种子的微粒体制剂在NADPH和O₂存在的情况下催化O-甲基安曲辛向去甲秋水仙碱的环扩展反应。此外，有证据表明在乙酰辅酶A和NADPH存在的情况下，去甲秋水仙碱会进一步转化为秋水仙碱。
