Kuenzle C, Steinlin M, Wohlrab G, Boltshauser E, Schmitt B
Department of Pediatric Neurology, University Children's Hospital, Zurich, Switzerland.
Epilepsia. 1998 Nov;39(11):1213-5. doi: 10.1111/j.1528-1157.1998.tb01314.x.
New antiepileptic drugs designed for enhancing GABAergic inhibition, such as vigabatrin (VGB) may be effective in Angelman syndrome (AS), because associated convulsions could be related to a reduced GABA-receptor density or receptor abnormality. From our preliminary experiences in four children with AS treated with VGB, we conclude that it may induce and increase seizures in patients with AS.
旨在增强γ-氨基丁酸（GABA）能抑制作用的新型抗癫痫药物，如氨己烯酸（VGB），可能对天使综合征（AS）有效，因为相关惊厥可能与GABA受体密度降低或受体异常有关。根据我们对4例接受VGB治疗的AS患儿的初步经验，我们得出结论，VGB可能会诱发并加重AS患者的癫痫发作。
