Di Vagno G, Cormio G, Loverro G, Melilli G A, Di Gesù G, Selvaggi L
Department of Obstetrics and Gynecology, University of Bari, Policlinico, Italy.
J Chemother. 1998 Oct;10(5):418-21. doi: 10.1179/joc.1998.10.5.418.
Malignant mixed müllerian tumors (MMMT) of the ovary are rare, aggressive and rapidly progressive tumors. According to the available literature, the presence of metastatic disease rarely permits long term survival. We report on a 64-year old patient with stage IV ovarian MMMT who achieved a surgically-documented complete response (CR) after 6 cycles of carboplatin, mesna, ifosfamide, cis-platin. Pelvic recurrence was diagnosed 14 months later; the patient received 6 cycles of the same regimen used as first-line chemotherapy which resulted in a second complete response lasting for 4 months. The patient died 37 months after initial diagnosis due to intestinal occlusion. In the current case Ca 125 was significantly increased at clinical presentation of disease but not at the time of recurrence.
卵巢恶性苗勒管混合瘤（MMMT）罕见、侵袭性强且进展迅速。根据现有文献，出现转移性疾病时很少能实现长期生存。我们报告一例64岁IV期卵巢MMMT患者，其在接受6个周期的卡铂、美司钠、异环磷酰胺和顺铂治疗后，经手术记录达到完全缓解（CR）。14个月后诊断出盆腔复发；患者接受了与一线化疗相同方案的6个周期治疗，再次实现了持续4个月的完全缓解。患者在初始诊断37个月后因肠梗阻死亡。在本例中，Ca 125在疾病临床表现时显著升高，但复发时未升高。
