Dong Z M, Wagner D D
Center for Blood Research and the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
J Lab Clin Med. 1998 Nov;132(5):369-75. doi: 10.1016/s0022-2143(98)90107-x.
The genetic manipulation of mice has provided an invaluable tool for studying the molecular mechanism(s) involved in atherosclerotic lesion development and maturation. The use of these new animal models has demonstrated that leukocyte-endothelium adhesion receptors play a significant part in promoting monocyte recruitment and consequently lesion growth. The next phase of investigation should test whether the inhibition of these adhesion receptors can reproduce the powerful anti-atherosclerotic effects seen in the adhesion receptor-deficient mice.
对小鼠的基因操作已为研究动脉粥样硬化病变发展和成熟过程中涉及的分子机制提供了一种极为宝贵的工具。这些新动物模型的应用表明，白细胞-内皮细胞黏附受体在促进单核细胞募集以及随后的病变生长中发挥着重要作用。下一阶段的研究应测试抑制这些黏附受体是否能重现黏附受体缺陷小鼠中所观察到的强大抗动脉粥样硬化作用。
