在应用萜类前体1-脱氧-D-木酮糖后会形成（-）-2-C-甲基-D-赤藓糖-1,4-内酯。

(-)-2C-methyl-D-erythrono-1,4-lactone is formed after application of the terpenoid precursor 1-deoxy-D-xylulose.

作者信息

Fellermeier M A, Maier U H, Sagner S, Bacher A, Zenk M H

机构信息

Institut für Pharmazie, Zentrum für Pharmaforschung, Ludwig-Maximilians-Universität München, Germany.

出版信息

FEBS Lett. 1998 Oct 23;437(3):278-80. doi: 10.1016/s0014-5793(98)01250-2.

DOI:10.1016/s0014-5793(98)01250-2

PMID:9824307

Abstract

Application of [1,2-14C]1-deoxy-D-xylulose, the committed precursor of terpenoids, thiamine and pyridoxol, to a variety of plant species resulted in the labelling of an unknown metabolite. The isolation and purification of this metabolite from Ipomoea purpurea plants fed with 1-deoxy-D-xylulose (DX), followed by NMR analysis, resulted in the identification of its structure as (-)-2C-methyl-D-erythrono-1,4-lactone (MDEL). MDEL has been previously isolated as a stress metabolite of certain plants. A hypothetical biosynthetic scheme is given.

摘要

萜类化合物、硫胺素和吡哆醇的直接前体[1,2-¹⁴C]1-脱氧-D-木酮糖应用于多种植物物种后，标记出一种未知代谢物。从用1-脱氧-D-木酮糖（DX）喂养的紫牵牛属植物中分离并纯化该代谢物，随后进行核磁共振分析，确定其结构为(-)-2C-甲基-D-赤藓糖-1,4-内酯（MDEL）。MDEL此前已作为某些植物的应激代谢物被分离出来。文中给出了一个假设的生物合成方案。