Xu Q W, Scott R B, Tan D T, Shaffer E A
GI Research Group, Department of Medicine, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.
Gut. 1998 Dec;43(6):817-22. doi: 10.1136/gut.43.6.817.
The ground squirrel on a high cholesterol diet exhibits prolonged intestinal transit, a pathogenetic factor in cholesterol gallstone formation.
To examine the effect of a high cholesterol diet on the characteristics of the migrating myoelectrical complex (MMC) and the potential benefit of erythromycin.
Twenty four animals received either a trace (controls) or a 1% (high) cholesterol diet. After four weeks, five bipolar jejunal and terminal ileal electrodes were implanted. Seven days later, myoelectric activity was measured in conscious, fasted animals before and after treatment with erythromycin. Biliary lipid composition was assessed.
Compared with controls, animals fed the high cholesterol diet exhibited a prolonged MMC cycle period (70 (6) versus 83 (3) minutes; p<0.05), whereas MMC migration velocity and the proportions of the MMC represented by phases I, II, and III were unchanged. Oral erythromycin significantly shortened the MMC cycle period in animals on the control and high cholesterol diet by 59% and 54% respectively, and increased the proportion of the cycle period occupied by phase III of the MMC in both dietary groups. Gall bladder bile became saturated with cholesterol and crystals developed in nine of 12 animals on the high cholesterol diet; controls had none.
Animals fed a high cholesterol diet had a prolonged MMC cycle period. This, along with diminished gall bladder motility, impairs the enterohepatic cycling of bile salts and reduces their hepatic secretion, contributing to the formation of abnormal bile. Erythromycin initiated more frequent cycling of the MMC. Its therapeutic value in cholesterol gallstone formation warrants further evaluation.
食用高胆固醇饮食的地松鼠肠道转运时间延长，这是胆固醇胆结石形成的一个致病因素。
研究高胆固醇饮食对移行性肌电复合波（MMC）特征的影响以及红霉素的潜在益处。
24只动物分别给予微量（对照组）或1%（高胆固醇组）胆固醇饮食。四周后，植入五对双极空肠和回肠末端电极。七天后，在清醒、禁食的动物身上测量红霉素治疗前后的肌电活动。评估胆汁脂质成分。
与对照组相比，食用高胆固醇饮食的动物MMC周期延长（70（6）分钟对83（3）分钟；p<0.05），而MMC迁移速度以及MMC各相（I相、II相和III相）所占比例未变。口服红霉素可使对照组和高胆固醇饮食组动物的MMC周期分别显著缩短59%和54%，并增加了两组饮食动物MMC III相所占周期比例。高胆固醇饮食组12只动物中有9只胆囊胆汁胆固醇饱和且出现结晶；对照组无此现象。
食用高胆固醇饮食的动物MMC周期延长。这与胆囊运动减弱一起，损害了胆盐的肠肝循环并减少了其肝脏分泌，导致异常胆汁形成。红霉素使MMC循环更频繁。其在胆固醇胆结石形成中的治疗价值值得进一步评估。
