Dobson L S, Hancock H, Bright N, Robinson M H, Hancock B W
Yorkshire Cancer Research Section of Clinical Oncology, Weston Park Hospital, Sheffield, S10 2SJ, UK.
Int J Oncol. 1998 Dec;13(6):1313-8. doi: 10.3892/ijo.13.6.1313.
We report a retrospective study of all patients with localised non-Hodgkin's lymphoma referred to the Sheffield Lymphoma Group (1970-1995). A total of 1,979 patients with non-Hodgkin's lymphoma were seen: 553 (28%) presented with stage I or II disease, 411 (21%) extranodal, 142 (7%) nodal. The commonest extranodal sites were head and neck, gastrointestinal tract, skin and central nervous system, accounting for 87% of patients. Most patients received primary localised radiotherapy. Overall observed survival was 52.5% at 5 years in the extranodal group and 65% in the nodal group. For both groups the 10-year observed survival was 42.5%. An age of 45 years and over was a poor prognostic factor in both groups (p<0.001). Patients with skin and non-Waldeyer's head and neck lymphomas survived best (5-year observed survivals 67 and 70% respectively) and CNS worst (5-year survival 38%). There is no cause for complacency in the management of localised non-Hodgkin's lymphoma, particularly for the less common extranodal sites where multicentre clinical studies are still essential.
我们报告了一项针对所有转诊至谢菲尔德淋巴瘤研究组（1970 - 1995年）的局限性非霍奇金淋巴瘤患者的回顾性研究。共诊治了1979例非霍奇金淋巴瘤患者：553例（28%）表现为I期或II期疾病，411例（21%）为结外病变，142例（7%）为淋巴结病变。最常见的结外病变部位是头颈部、胃肠道、皮肤和中枢神经系统，占患者总数的87%。大多数患者接受了原发性局部放疗。结外病变组5年总观察生存率为52.5%，淋巴结病变组为65%。两组的10年观察生存率均为42.5%。45岁及以上在两组中都是不良预后因素（p<0.001）。皮肤和非瓦尔代尔环头颈部淋巴瘤患者生存情况最佳（5年观察生存率分别为67%和70%），中枢神经系统病变患者最差（5年生存率为38%）。在局限性非霍奇金淋巴瘤的治疗中不能自满，特别是对于较不常见的结外病变部位，多中心临床研究仍然至关重要。
