Effect of the beta 1-blocker/beta 2-agonist celiprolol on atrial natriuretic peptide plasma levels in hypertensive patients.

The aim of this study was to evaluate the long-term effects of the selective beta 1-blocker/beta 2-agonist celiprolol on atrial natriuretic peptide (ANP) levels in patients with moderate essential hypertension. The drug was given orally in a daily dose of 200 mg for 30 days. Plasma ANP levels increased by 187% despite the drop in blood pressure, while left atrial and ventricular diameters remained unchanged. These findings indicate that ANP secretion, which is mediated by beta 1-receptor blockade, is not affected by stimulation of the vasodilatory beta 2-receptors. There is strong evidence suggesting that beta-blockers exert part of their antihypertensive action by increasing ANP secretion.