Drell D W, Wegmann T G
Transplant Proc. 1976 Sep;8(3):363-7.
The effect of varying the H-2 complex on the survival of parabiosed mice was investigated using a strain combination known to lead to about 50% long-term survival. While 45.6% of DBA/2J (H-2d) with (DBA/2J x C3H/HeJ)F1 (H-2d/H-2k) parabionts survive to 100 days or more, 69% of DBA/2J with (DBA/2J x C3H.NBSn)F1s (H-2d/H-2p) survive that long; only 16% of DBA/2J with (DBA/2Jx C3H.SWSn)F1s (H-2d/H-2b) survive to 100 days. The plot of hematocrits as a function of time after parabiosis differs significantly between the 45.6% surviving strain combination (which shows the classical pattern of parental polycythemia and F1 hybrid anemia) and the 69% surviving strain combination (which shows no divergence in parental and F1 hematocrit values). Furthermore, the 69% surviving strain combination often (5/14) persists in a chimeric state as judgec by starch gel electrophoresis of rec blood cell lysates; the other two strain combinations show no demonstrable red cell chimerism. The conclusion is suggested that the mechann these two generally successful strain combinations tested, and appears to be a function of the H-2types of the partners.
利用一种已知能使约50%的联体小鼠长期存活的品系组合，研究了改变H-2复合体对联体小鼠存活的影响。在（DBA/2J×C3H/HeJ）F1（H-2d/H-2k）联体的DBA/2J小鼠中，45.6%存活至100天或更长时间；在（DBA/2J×C3H.NBSn）F1（H-2d/H-2p）联体的DBA/2J小鼠中，69%存活至同样长的时间；在（DBA/2J×C3H.SWSn）F1（H-2d/H-2b）联体的DBA/2J小鼠中，只有16%存活至100天。联体后血细胞比容随时间变化的曲线在45.6%存活的品系组合（显示出亲代红细胞增多症和F1杂种贫血的经典模式）和69%存活的品系组合（亲代和F1血细胞比容值无差异）之间有显著不同。此外，通过对回收的红细胞裂解物进行淀粉凝胶电泳判断，69%存活的品系组合经常（5/14）处于嵌合状态；另外两个品系组合未显示出可证实的红细胞嵌合现象。由此得出结论，这两个测试的通常成功的品系组合的机制似乎是伙伴的H-2类型的作用。 （注：原文中“mechann”应改为“mechanism” ，“rec”应改为“recovered” ，“judgec”应改为“judged” ，翻译时按正确内容翻译。）
