生长抑素类似物在乳腺癌治疗中的潜在作用。
The potential role of somatostatin analogues in breast cancer treatment.
作者信息
Pollak M
机构信息
Department of Medicine, McGill University, Montreal, Canada.
出版信息
Yale J Biol Med. 1997 Sep-Dec;70(5-6):535-9.
Abstract
Existing treatments for breast cancer are helpful for many patients, but treatment failure remains a common event, and there is a strong clinical need to improve upon current therapies. Somatostatin analogues have been evaluated for antineoplastic activity in model systems over the past decade, and encouraging results have been obtained (reviewed in [1, 2]). This has led to suggestions to test these agents clinically in the treatment of breast cancer patients, and a program of clinical trials has recently been initiated. This review will describe aspects of research in this area.
摘要
现有的乳腺癌治疗方法对许多患者有帮助，但治疗失败仍是常见情况，临床上迫切需要改进当前疗法。在过去十年中，已在模型系统中评估了生长抑素类似物的抗肿瘤活性，并取得了令人鼓舞的结果（见[1, 2]综述）。这促使人们建议在乳腺癌患者的临床治疗中测试这些药物，最近已启动了一项临床试验计划。本综述将描述该领域的研究情况。
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本文引用的文献
1
Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3.人类生长抑素受体3对野生型p53的亚型选择性诱导及凋亡诱导作用，但不引起细胞周期阻滞。
Mol Endocrinol. 1996 Dec;10(12):1688-96. doi: 10.1210/mend.10.12.8961277.
2
A role for insulin-like growth factor binding protein 5 in the antiproliferative action of the antiestrogen ICI 182780.胰岛素样生长因子结合蛋白5在抗雌激素ICI 182780的抗增殖作用中的作用。
Cell Growth Differ. 1996 Nov;7(11):1501-6.
3
Relative weight, weight change, height, and breast cancer risk in Asian-American women.亚裔美国女性的相对体重、体重变化、身高与乳腺癌风险
J Natl Cancer Inst. 1996 May 15;88(10):650-60. doi: 10.1093/jnci/88.10.650.
4
Reduced growth of human breast cancer xenografts in hosts homozygous for the lit mutation.在纯合子携带lit突变的宿主中，人乳腺癌异种移植瘤生长减缓。
Cancer Res. 1996 Apr 1;56(7):1509-11.
5
Estradiol and antiestrogens regulate a growth inhibitory insulin-like growth factor binding protein 3 autocrine loop in human breast cancer cells.雌二醇和抗雌激素调节人乳腺癌细胞中一种生长抑制性胰岛素样生长因子结合蛋白3自分泌环。
J Biol Chem. 1996 Jan 12;271(2):1016-21. doi: 10.1074/jbc.271.2.1016.
6
Octreotide.奥曲肽
N Engl J Med. 1996 Jan 25;334(4):246-54. doi: 10.1056/NEJM199601253340408.
7
In vivo inhibition of insulin-like growth factor I gene expression by tamoxifen.他莫昔芬对胰岛素样生长因子I基因表达的体内抑制作用。
Cancer Res. 1993 Apr 15;53(8):1727-30.
8
The insulin-like growth factors.胰岛素样生长因子
Annu Rev Physiol. 1993;55:131-53. doi: 10.1146/annurev.ph.55.030193.001023.
9
Diet, body size, and breast cancer.饮食、体型与乳腺癌。
Epidemiol Rev. 1993;15(1):110-32. doi: 10.1093/oxfordjournals.epirev.a036096.
10
Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index.1030名健康儿童、青少年及成人的血清胰岛素样生长因子-I：与年龄、性别、青春期阶段、睾丸大小及体重指数的关系
J Clin Endocrinol Metab. 1994 Mar;78(3):744-52. doi: 10.1210/jcem.78.3.8126152.
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