生长抑素受体闪烁显像在肾上腺肿瘤管理中的生物学及临床相关性
The biology and clinical relevance of somatostatin receptor scintigraphy in adrenal tumor management.
作者信息
Kennedy J W, Dluhy R G
机构信息
Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
出版信息
Yale J Biol Med. 1997 Sep-Dec;70(5-6):565-75.
Abstract
Somatostatin receptors are present in the normal adrenal cortex and medulla. These receptors are also expressed by tumors that cause Cushing's syndrome and by pheochromocytomas. Somatostatin analogues such as octreotide have been developed to target somatostatin receptors for diagnostic and therapeutic purposes. This article reviews the current knowledge of the biology of somatostatin receptors in the normal adrenal gland and in adrenal tumors and defines the current role of the somatostatin receptor in the diagnosis, staging and management of Cushing's syndrome and pheochromocytomas.
摘要
生长抑素受体存在于正常肾上腺皮质和髓质中。这些受体也表达于导致库欣综合征的肿瘤以及嗜铬细胞瘤中。已开发出如奥曲肽等生长抑素类似物，以靶向生长抑素受体用于诊断和治疗目的。本文综述了正常肾上腺及肾上腺肿瘤中生长抑素受体生物学的现有知识，并明确了生长抑素受体在库欣综合征和嗜铬细胞瘤的诊断、分期及管理中的当前作用。
相似文献
1
The biology and clinical relevance of somatostatin receptor scintigraphy in adrenal tumor management.生长抑素受体闪烁显像在肾上腺肿瘤管理中的生物学及临床相关性
Yale J Biol Med. 1997 Sep-Dec;70(5-6):565-75.
2
Somatostatin receptor subtypes in human pheochromocytoma: subcellular expression pattern and functional relevance for octreotide scintigraphy.人类嗜铬细胞瘤中的生长抑素受体亚型：亚细胞表达模式及其与奥曲肽闪烁扫描的功能相关性
J Clin Endocrinol Metab. 2003 Nov;88(11):5150-7. doi: 10.1210/jc.2003-030262.
3
[Adrenal gland scintigraphy].
Radiologe. 1986 Apr;26(4):181-5.
4
A reappraisal of the utility of somatostatin receptor scintigraphy in patients with ectopic adrenocorticotropin Cushing's syndrome.对生长抑素受体闪烁扫描术在异位促肾上腺皮质激素性库欣综合征患者中效用的重新评估。
J Clin Endocrinol Metab. 2003 Oct;88(10):4754-8. doi: 10.1210/jc.2003-030525.
5
[Adrenal scintigraphy-value and indications in adrenal disease].
Helv Chir Acta. 1979 Aug;46(3):283-6.
6
Immunohistochemical localization and functional characterization of somatostatin receptor subtypes in a corticotropin releasing hormone- secreting adrenal phaeochromocytoma: review of the literature and report of a case.促肾上腺皮质激素释放激素分泌型肾上腺嗜铬细胞瘤中生长抑素受体亚型的免疫组化定位及功能特征：文献综述及病例报告
Eur J Histochem. 2009 Jan-Mar;53(1):1-6.
7
Potential indications for somatostatin analogs in Cushing's syndrome.库欣综合征中生长抑素类似物的潜在适应证。
J Endocrinol Invest. 2005;28(11 Suppl International):106-10.
8
ACTH-producing pheochromocytoma: clinical considerations and concise review of the literature.促肾上腺皮质激素（ACTH）分泌性嗜铬细胞瘤：临床相关问题及文献复习概要。
Eur J Intern Med. 2009 Nov;20(7):682-5. doi: 10.1016/j.ejim.2009.08.002. Epub 2009 Aug 31.
9
[Radiological signs of tumours of the adrenal glands (author's transl)].
Sem Hop. 1978;54(25-28):839-45.
10
[A case of Cushing's syndrome due to adrenal carcinoma (author's transl)].
Rinsho Hoshasen. 1978 Sep;23(9):977-80.
引用本文的文献
1
Does somatostatin have a role in the regulation of cortisol secretion in primary pigmented nodular adrenocortical disease (ppnad)? a clinical and in vitro investigation.生长抑素在原发性色素结节性肾上腺皮质疾病（PPNAD）中对皮质醇分泌的调节作用：一项临床和体外研究。
J Clin Endocrinol Metab. 2014 May;99(5):E891-901. doi: 10.1210/jc.2013-2657. Epub 2014 Feb 10.
本文引用的文献
1
Octreotide.奥曲肽
N Engl J Med. 1996 Jan 25;334(4):246-54. doi: 10.1056/NEJM199601253340408.
2
Molecular biology of somatostatin receptors.生长抑素受体的分子生物学
Endocr Rev. 1995 Aug;16(4):427-42. doi: 10.1210/edrv-16-4-427.
3
Somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients.使用[111In-DTPA-D-Phe1] - 和[123I-Tyr3] - 奥曲肽的生长抑素受体闪烁扫描术：鹿特丹对1000多名患者的经验
Eur J Nucl Med. 1993 Aug;20(8):716-31. doi: 10.1007/BF00181765.
4
Validation of somatostatin receptor scintigraphy in the localization of neuroendocrine tumors.
Acta Oncol. 1993;32(2):167-70. doi: 10.3109/02841869309083907.
5
Effect of octreotide on catecholamine plasma levels in patients with chromaffin cell tumors.
Horm Res. 1993;40(4):156-60. doi: 10.1159/000183786.
6
Localization of endocrine tumors with radiolabeled octreotide.
Radiology. 1994 Apr;191(1):289-91. doi: 10.1148/radiology.191.1.8166870.
7
Somatostatin receptor scintigraphy: its value in tumor localization in patients with Cushing's syndrome caused by ectopic corticotropin or corticotropin-releasing hormone secretion.生长抑素受体闪烁扫描术：其在由异位促肾上腺皮质激素或促肾上腺皮质激素释放激素分泌引起的库欣综合征患者肿瘤定位中的价值。
Am J Med. 1994 Apr;96(4):305-12. doi: 10.1016/0002-9343(94)90059-0.
8
Identification of somatostatin receptor subtypes and an implication for the efficacy of somatostatin analogue SMS 201-995 in treatment of human endocrine tumors.生长抑素受体亚型的鉴定及其对生长抑素类似物SMS 201-995治疗人类内分泌肿瘤疗效的影响。
J Clin Invest. 1994 Mar;93(3):1321-5. doi: 10.1172/JCI117090.
9
Pheochromocytoma.嗜铬细胞瘤
Endocrinol Metab Clin North Am. 1994 Jun;23(2):387-404.
10
Localization of adrenocorticotropic hormone-secreting bronchial carcinoid tumor by somatostatin-receptor scintigraphy.通过生长抑素受体闪烁扫描法对促肾上腺皮质激素分泌型支气管类癌瘤进行定位
Ann Intern Med. 1994 Aug 1;121(3):198-9. doi: 10.7326/0003-4819-121-3-199408010-00007.
Zotero 插件