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左卡巴斯汀治疗12岁以下季节性变应性鼻炎和结膜炎儿童的临床疗效及安全性

[Clinical efficacy and safety of levocarbastine++ in the therapy in children suffering from seasonal allergic rhinitis and conjunctivitis who are less than 12 year of age].

作者信息

Kurzawa R, Kossek M, Doniec Z, Mazurek H, Urbanek E, Sak-Kopytyńska I, Radliński J, Bukowczan Z

机构信息

Instytutu Gruźlicy i Chorób Płuc Oddział w Rabce.

出版信息

Pol Merkur Lekarski. 1998 May;4(23):269-72.

PMID:9825660
Abstract

Levocabastine is an antihistaminic agent for topical application. It is without not advisable general side-effects and since many years is widely used for the treatment of pollinosis in adults and children more than 12 years of age. The group of 32 children aged from 5 to 11 years suffering from seasonal allergic rhinitis and conjunctivitis were treated by means of levocabastine applied topically by 20 days during the period of natural exposition to grass pollen. The clinical efficacy and tolerability including potential side-effects, were evaluated on the basis of clinical-laryngological investigations, visual analogs scales and diary cards filed in by parents of examined children. Levocabastine has been demonstrated to have rapid onset of action in children with SAR and the topical application of the drug does not irritate the mucosa of conjunctivas and nasal cavities.

摘要

左卡巴斯汀是一种用于局部应用的抗组胺药。它没有不可取的一般副作用,多年来一直广泛用于治疗12岁及以上成人和儿童的花粉症。对32名年龄在5至11岁、患有季节性过敏性鼻炎和结膜炎的儿童,在自然接触草花粉期间,通过局部应用左卡巴斯汀治疗20天。根据临床 - 喉科学检查、视觉模拟量表以及受检儿童家长填写的日记卡,对临床疗效和耐受性(包括潜在副作用)进行了评估。已证明左卡巴斯汀对季节性变应性鼻炎儿童起效迅速,且该药物的局部应用不会刺激结膜和鼻腔黏膜。

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