Longui C A, Vottero A, Harris A G, Chrousos G P
Pediatric Endocrinology Section, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1862, USA.
Metabolism. 1998 Nov;47(11):1419-22. doi: 10.1016/s0026-0495(98)90316-x.
Intravenous infusion of corticotropin 1-24 (ACTH 1-24) followed by a plasma cortisol measurement after 60 minutes of less than 20 microg/dL indicates clinically important glucocorticoid deficiency. In this study, we evaluated the morning plasma cortisol response to an intramuscular (IM) injection of ACTH 1-24 (250 microg) in 64 healthy men. Plasma cortisol increased significantly 30 and 60 minutes after IM ACTH 1-24 (P < .0001). In most subjects, a maximal response was obtained at 60 minutes. The cortisol response correlated positively with the morning basal cortisol concentration. The lowest cortisol peak and the lowest increment observed after IM ACTH 1-24 were, respectively, 12.6 and 3.5 microg/dL after 30 minutes and 16.3 and 5.3 microg/dL after 60 minutes. We conclude that a plasma cortisol level less than 16.0 microg/dL 60 minutes after IM ACTH 1-24 can be used as an index of glucocorticoid deficiency.
静脉输注促肾上腺皮质激素1 - 24（ACTH 1 - 24），60分钟后血浆皮质醇测量值低于20微克/分升表明存在具有临床意义的糖皮质激素缺乏。在本研究中，我们评估了64名健康男性肌肉注射（IM）ACTH 1 - 24（250微克）后早晨血浆皮质醇的反应。肌肉注射ACTH 1 - 24后30分钟和60分钟，血浆皮质醇显著升高（P <.0001）。在大多数受试者中，60分钟时获得最大反应。皮质醇反应与早晨基础皮质醇浓度呈正相关。肌肉注射ACTH 1 - 24后观察到的最低皮质醇峰值和最低增加值分别为：30分钟后为12.6微克/分升和3.5微克/分升，60分钟后为16.3微克/分升和5.3微克/分升。我们得出结论，肌肉注射ACTH 1 - 24后60分钟血浆皮质醇水平低于16.0微克/分升可作为糖皮质激素缺乏的指标。
