Bronshtein M, Zimmer E Z, Blazer S
Department of Obstetrics and Gynecology, Rambam Medical Center, Faculty of Medicine, Haifa, Israel.
Prenat Diagn. 1998 Oct;18(10):997-1000.
Twenty-one fetuses with an enlarged fourth ventricle were detected by ultrasound at 14-16 weeks' gestation. No other central nervous system anomalies were observed and a normal size fourth ventricle was noted in all cases on follow-up scans at 22-23 weeks' gestation. Five fetuses had associated structural anomalies: a single umbilical artery in two cases, non-septated cystic hygroma in two cases and ventricular septal defect in one fetus. All fetuses had a normal brain sonogram after delivery. Nineteen newborns who were followed up to the age of one year had no developmental problems. It is concluded that an isolated enlarged fourth ventricle might be a physiological variant in early fetal life.
在妊娠14 - 16周时，超声检测到21例胎儿第四脑室增大。未观察到其他中枢神经系统异常，且在妊娠22 - 23周的随访扫描中，所有病例的第四脑室大小均正常。5例胎儿伴有结构异常：2例为单脐动脉，2例为非分隔性囊状水瘤，1例胎儿为室间隔缺损。所有胎儿出生后脑超声检查均正常。对19例随访至1岁的新生儿进行检查，未发现发育问题。结论是，孤立性第四脑室增大可能是胎儿早期的一种生理变异。
