Villena I, Chemla C, Quereux C, Dupouy D, Leroux B, Foudrinier F, Pinon J M
Laboratory of Parasitology-Mycology, Team 4 (Inserm U.314), Hôpital Maison Blanche, Reims, France.
Prenat Diagn. 1998 Oct;18(10):1079-81.
We report a rare case of congenital toxoplasmosis transmitted by an immunocompetent woman infected before conception. Active toxoplasmosis was suspected due to persistent lymphadenitis with specific IgM, IgA, IgE antibodies. Prenatal diagnosis based on amniocentesis and fetal blood sampling at 24 weeks' amenorrhoea was positive on amniotic fluid, and fetal infection was confirmed after termination. In our opinion such cases need the same monitoring as when seroconversion occurs during the first trimester. A pregnancy-free interval of six to nine months is recommended after proven patent toxoplasmosis seroconversion.
我们报告了一例罕见的先天性弓形虫病病例，该病由一名在受孕前感染的免疫功能正常的女性传播。由于持续性淋巴结炎伴特异性IgM、IgA、IgE抗体，怀疑存在活动性弓形虫病。在闭经24周时通过羊膜穿刺术和胎儿采血进行的产前诊断显示羊水检测呈阳性，终止妊娠后确诊胎儿感染。我们认为，此类病例需要与孕早期血清学转换时相同的监测。在确诊弓形虫病血清学转换后，建议有6至9个月的无妊娠间隔期。
