[塞内加尔人群中的人类白细胞抗原标记物与糖尿病视网膜病变]

[HLA-markers and diabetic retinopathy in the Senegalese population].

作者信息

Cisse A, Chevenne D, Chauffert M, Ndiaye M R, Wade A, Trivin F

机构信息

Laboratoire de Physique Pharmaceutique, Faculté de Médecine et de Pharmacie, Université Cheikh Anta Diop, Dakar, Sénégal.

出版信息

Dakar Med. 1998;43(1):29-33.

PMID:9827151

Abstract

Patients with IDDM often develop severe forms of retinopathy, supposed to be associated to risk factors such as hypertension, poor glycemic control and nephropathy. A controversial intervention of a genetic marker was evoked so as some diabetic patients have retinopathy in the absence of known risk factors. HLA-DR and DQ markers were compared in two groups of patients with IDDM respectively constituted of patients with and without severe retinopathy. HLA typing was carried out by polymerase chain reaction (PCR) and restriction fragments of length polymorphism (RFLP). DR9 (p < 10(-4); O.R. = 8.36) and DQA10301 (p < 0.05; O.R = 2.92) alleles were positively associated to diabetic retinopathy, at the opposite of DR3 (p < 10(-3); O.R: 0.01) and DQA1 (p < 10(-9); O.R = 0.15). Furthermore, among the genotypes previously considered as risk markers of IDDM in senegalese people, only DR4: DQA10301:DQB10302/DR9: DQA10301: DQB10201 was often observed in retinopathy.

摘要

胰岛素依赖型糖尿病（IDDM）患者常出现严重形式的视网膜病变，推测这与高血压、血糖控制不佳和肾病等危险因素有关。由于一些糖尿病患者在没有已知危险因素的情况下也会出现视网膜病变，因此引发了对一种遗传标记的争议性干预。分别在两组IDDM患者中比较了HLA - DR和DQ标记，这两组患者分别由有和没有严重视网膜病变的患者组成。通过聚合酶链反应（PCR）和限制性片段长度多态性（RFLP）进行HLA分型。DR9（p < 10⁻⁴；优势比 = 8.36）和DQA10301（p < 0.05；优势比 = 2.92）等位基因与糖尿病视网膜病变呈正相关，与DR3（p < 10⁻³；优势比：0.01）和DQA1（p < 10⁻⁹；优势比 = 0.15）相反。此外，在先前被认为是塞内加尔人IDDM风险标记的基因型中，只有DR4:DQA10301:DQB10302/DR9:DQA10301:DQB10201在视网膜病变中经常被观察到。