WAY-100635 reverses 8-OH-DPAT-induced performance impairment in the radial maze.
作者信息
Helsley S, Siegel T L, Fiorella D, Rabin R A, Winter J C
机构信息
Department of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1998 Oct;22(7):1179-84. doi: 10.1016/s0278-5846(98)00068-2.
PMID:9829296
Abstract
- The effects of the 5-HT1A receptor agonist, (8-OH-DPAT), alone and in combination with the selective 5-HT1A antagonist, WAY-100635, were assessed in Fischer-344 rats in an 8-arm radial maze. 2. At a dose of 1.0 mg/kg, 8-OH-DPAT significantly reduced both efficiency of performance (% correct arm entries) and response rate (arms/min) compared with the saline condition. 3. These effects were completely blocked by WAY-100635 which by itself had no effect on efficiency or response rate. 4. WAY-100635 inhibits 8-OH-DPAT-induced impairment in radial maze performance.
摘要
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