Culbert P, Gillett H, Ferguson A
Gastro-Intestinal Unit, University of Edinburgh, Department of Medicine, Western General Hospital, Edinburgh.
Br J Gen Pract. 1998 Sep;48(434):1599-600.
We reasoned that relief of faecal impaction could be achieved if a bolus of polyethylene glycol/electrolyte solution was delivered to the caecum over a few hours. Thus, 16 patients with faecal impaction (duration of constipation 5-23 days) were treated in an open study with up to three daily treatments of one litre of polyethylene glycol/electrolyte solution daily, taken orally over 4-6 hours. Complete resolution of impaction, strictly defined, was obtained in 13 patients, and significant improvement in the other three. Only one patient was faecally incontinent and the only side-effect was an increase in borborygmi. Polyethylene glycol/electrolyte solution, given as a treatment dose of one litre daily for up to three days, is a highly effective and acceptable oral therapy for faecal impaction.
我们推断，如果在数小时内将大剂量聚乙二醇/电解质溶液送达盲肠，就可以缓解粪便嵌塞。因此，在一项开放性研究中，对16例粪便嵌塞患者（便秘持续时间为5 - 23天）进行了治疗，每天最多进行三次治疗，每次口服一升聚乙二醇/电解质溶液，在4 - 6小时内服完。严格定义下，13例患者的嵌塞完全解除，另外3例有显著改善。只有1例患者出现大便失禁，唯一的副作用是肠鸣音增加。聚乙二醇/电解质溶液，以每天一升的治疗剂量连续使用最多三天，是一种治疗粪便嵌塞高效且可接受的口服疗法。
