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在一家郊区诊所,使用聚乙二醇电解质散和匹可硫酸钠,在3至4天内解除重度便秘儿童的粪块嵌塞。

Disimpaction of children with severe constipation in 3-4 days in a suburban clinic using polyethylene glycol with electrolytes and sodium picosulphate.

作者信息

Jordan-Ely Julie, Hutson John M, Southwell Bridget R

机构信息

Surgical Research Group, Murdoch Childrens Research Institute, Melbourne, Australia.

Urology Department, The Royal Children's Hospital, Melbourne, Australia.

出版信息

J Paediatr Child Health. 2015 Dec;51(12):1195-8. doi: 10.1111/jpc.12939. Epub 2015 Jun 8.

DOI:10.1111/jpc.12939
PMID:26059611
Abstract

AIM

Constipation is a common cause of admission to hospital for disimpaction, as oral laxatives are often inadequate. High-dose oral laxative protocols are used for complete bowel clearance prior to colonoscopy, but have not been reported for treating faecal impaction. The aim of this study was to assess the effectiveness of a high-dose oral protocol using polyethylene glycol with electrolytes (PEG + E) (Movicol Rx) combined with sodium picosulphate (SP) (Dulcolax SP Rx) in faecal impaction in children presenting to a suburban clinic.

METHODS

Forty-four children presented with acute/chronic faecal impaction were given six to eight sachets of PEG + E were given on day 1, with decreasing doses on subsequent 3 days, while 15-20 SP drops were given on days 2 and 3. Compliance with medication was achieved using a simple method of motivation, with the child drinking the laxatives in a race. On day 4, PEG + E was reduced to one sachet and SP to 10 drops as an ongoing maintenance dose. Defecation, soiling, diet and water intake was monitored daily for 7 days in a diary.

RESULTS

Forty-four children (aged 2-17 years) seen over 8 months were reviewed retrospectively. Children began defecating within 10-12 h reaching a maximum volume of stool/day (four cups) on day 2. All patients were disimpacted successfully and in the week following disimpaction there was no reported faecal soiling or complications.

CONCLUSIONS

A high-dose oral protocol combining PEG + E sachets and SP drops successfully and safely disimpacted a cohort of children with acute/chronic constipation presenting to a suburban continence clinic. This protocol appears to be useful to control faecal disimpaction in an outpatient setting, thereby avoiding hospital admission.

摘要

目的

便秘是因粪便嵌塞而住院的常见原因,因为口服泻药往往效果不佳。高剂量口服泻药方案用于结肠镜检查前的完全肠道清洁,但尚未见用于治疗粪便嵌塞的报道。本研究的目的是评估使用聚乙二醇电解质散(PEG + E)(福松Rx)联合匹可硫酸钠(SP)(杜密克SP Rx)的高剂量口服方案对一家郊区诊所就诊的儿童粪便嵌塞的疗效。

方法

44例患有急性/慢性粪便嵌塞的儿童在第1天给予6至8包PEG + E,随后3天剂量递减,同时在第2天和第3天给予15 - 20滴SP。通过一种简单的激励方法使患儿配合用药,让孩子在比赛中喝下泻药。第4天,PEG + E减至1包,SP减至10滴作为维持剂量。连续7天每天通过日记监测排便、弄脏内裤情况、饮食和水摄入量。

结果

回顾性分析了8个月内就诊的44例儿童(年龄2 - 17岁)。儿童在10 - 12小时内开始排便,第2天粪便量达到每日最大量(四杯)。所有患者均成功解除粪便嵌塞,解除嵌塞后的一周内未报告有粪便弄脏内裤或并发症。

结论

联合使用PEG + E散剂和SP滴剂的高剂量口服方案成功且安全地解除了一群到郊区节制门诊就诊的急性/慢性便秘儿童的粪便嵌塞。该方案似乎有助于在门诊环境中控制粪便嵌塞,从而避免住院治疗。

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