Peusch-Dreyer D, Dreyer K H, Müller C D, Carl U
Zentrum für Tauch- und Uberdruckmedizin-ZETUM, Bremen.
Strahlenther Onkol. 1998 Nov;174 Suppl 3:99-100.
In many case reports the success of treatment of late complications of radiotherapy with hyperbaric oxygenation (HBO) has been shown. This synopsis attempts to review HBO in the treatment of chronic radiation injury of the bladder.
Three female patients who had developed urge-incontinence after a Wertheim operation and combined brachy-teletherapy with cobalt-60 and afterloading and did not respond to various drug therapies, were treated with HBO to a maximum of 40 applications.
In all patients HBO altered and inverted the dynamic process underlying chronic bladder changes after irradiation. Rationales for the HBO are the reduction of tissue hypoxia and the induction of neoangiogenesis.
There are no prospective trials up to date showing the benefit of HBO to urinary disorders caused by radiation cystitis. The positive results of our retrospective study should encourage clinicians to initiate prospective studies with the use of HBO in the treatment of radiation cystitis.
在许多病例报告中已显示高压氧疗法（HBO）治疗放疗晚期并发症取得成功。本综述旨在探讨HBO在治疗膀胱慢性放射性损伤中的应用。
3例女性患者在进行韦特海姆手术及钴 - 60近距离后装放疗后出现急迫性尿失禁，且对多种药物治疗均无反应，接受了最多40次的HBO治疗。
在所有患者中，HBO改变并逆转了放疗后慢性膀胱变化的动态过程。HBO治疗的原理是减少组织缺氧并诱导新生血管形成。
目前尚无前瞻性试验表明HBO对放射性膀胱炎所致泌尿系统疾病有益。我们的回顾性研究的阳性结果应鼓励临床医生开展关于使用HBO治疗放射性膀胱炎的前瞻性研究。
