Austin D J, Bonten M J
Wellcome Trust Centre for the Epidemiology of Infectious Diseases, University of Oxford, UK.
Mem Inst Oswaldo Cruz. 1998 Sep-Oct;93(5):587-8. doi: 10.1590/s0074-02761998000500005.
Vancomycin-resistant enterococci (VRE) have recently emerged as a nosocomial pathogen and present an increasing threat to the treatment of severely ill patients in intensive-care hospital settings. We outline results of a study of the epidemiology of VRE transmission in ICUs and define a reproductive number R0; the number of secondary colonization cases induced by a single VRE-colonized patient in a VRE-free ICU, for VRE transmission. For VRE to become endemic requires R0 > 1. We estimate that in the absence of infection control measures R0 lies in the range 3-4 in defined ICU settings. Once infection control measures are included R0 = 0.6, suggesting that admission of VRE-colonized patients can stabilize endemic VRE.
耐万古霉素肠球菌（VRE）最近已成为一种医院病原体，对重症监护病房中重症患者的治疗构成越来越大的威胁。我们概述了一项关于重症监护病房中VRE传播流行病学的研究结果，并定义了一个繁殖数R0；即一名VRE定植患者在无VRE的重症监护病房中引发的继发性定植病例数，用于VRE传播。要使VRE成为地方病，需要R0>1。我们估计，在没有感染控制措施的情况下，在特定的重症监护病房环境中，R0在3至4之间。一旦纳入感染控制措施，R0 = 0.6，这表明VRE定植患者的入院可以使VRE地方病稳定下来。
