遗传性肾肿瘤
Inherited renal neoplasms.
作者信息
Torres V E, Bjornsson J, Zincke H
机构信息
Division of Nephrology, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA.
出版信息
J Nephrol. 1998 Sep-Oct;11(5):229-38.
PMID:9831235
Abstract
The application of positional cloning to the study of families with inherited renal neoplasms has allowed the identification of genes which are also important in the pathogenesis of sporadic tumors and has advanced the understanding of the mechanisms underlying renal carcinogenesis. This review provides a discussion of these mechanisms as well as the diagnosis and management of the inherited renal neoplasms.
摘要
将定位克隆技术应用于遗传性肾肿瘤家族的研究，使得人们能够鉴定出在散发性肿瘤发病机制中也起重要作用的基因，并增进了对肾肿瘤发生机制的理解。本综述讨论了这些机制以及遗传性肾肿瘤的诊断和治疗。
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