Merz U, Kusenbach G, Häusler M, Peschgens T, Hörnchen H
Children's Hospital, Neonatal Intensive Care Unit, Aachen University of Technology, Aachen, Germany.
Biol Neonate. 1999;75(1):46-53. doi: 10.1159/000014076.
The aim of this randomized, double-blind pilot study was to evaluate the short-term efficacy of early inhalation therapy with budesonide in ventilator-dependent preterm infants. The primary outcome variable was the duration of artificial ventilation; secondary outcome variables were the need for supplemental oxygen and the release of several inflammatory mediators in the tracheobronchial aspirate fluid. The infants of the budesonide group could not be weaned earlier from the ventilator. The ventilatory parameters on day 14 of life and the need for supplemental oxygen were similar in both groups. The release of inflammatory mediators was not reduced in the budesonide group. No adverse side effects were observed in either group. In conclusion, aerosolized budesonide failed to demonstrate significant short-term pulmonary improvement in ventilator-dependent preterm infants.
这项随机、双盲的试点研究旨在评估布地奈德早期吸入疗法对依赖呼吸机的早产儿的短期疗效。主要结局变量是人工通气的持续时间；次要结局变量是补充氧气的需求以及气管支气管吸出液中几种炎症介质的释放情况。布地奈德组的婴儿未能更早地撤掉呼吸机。两组在出生后第14天的通气参数以及补充氧气的需求相似。布地奈德组炎症介质的释放并未减少。两组均未观察到不良副作用。总之，雾化布地奈德未能在依赖呼吸机的早产儿中显示出显著的短期肺部改善效果。
