De Lima J J, Colombo F M, Lopes H F, Riccio G M, Krieger E M
Hypertension Unit, Heart Institute, São Paulo University Medical School, Brazil.
Am J Hypertens. 1998 Nov;11(11 Pt 1):1371-5. doi: 10.1016/s0895-7061(98)00156-3.
The acute hemodynamic effect of cyclosporine in man is controversial. A randomized, double blind, placebo-controlled, cross-over study was undertaken to evaluate the effect of a single oral dose of cyclosporine (20 mg/kg body weight) on mean blood pressure (MBP), heart rate (HR), forearm blood flow (FBF), and vascular resistance (FVR) in 16 healthy adult subjects. Subjects were studied twice, with an intervening period of 2 weeks, before and after the administration of either cyclosporine or the vehicle olive oil. Blood pressure was measured on brachial and digital arteries. After 30 min of rest, basal measurements were obtained and individuals were randomly assigned to receive either cyclosporine or the vehicle, and the same measurements were repeated 2 h later. Mean whole blood levels of cyclosporine were 1542+/-387 ng/mL (range 1000 to 2550) 2 h after the administration of a single oral dose of cyclosporine. Cyclosporine did not cause any significant change in the hemodynamic parameters when compared with vehicle. Pre- and post-cyclosporine data were as follows (means +/-/SD): MBP (determined by Finapres on the digital artery), 92+/-10 v 95+/-11 mm Hg; HR, 66+/-10 v 68+/-11 beats/min; FBF, 3.90+/-1.3 v 3.8+/-1.8 mL/ 100 mL/min; and FVR, 28+/-9 v 33 +/-18 units, respectively. For the vehicle the results were: MBP, 94+/-9 v 94+/-9; HR, 67+/-9v 67 /-11; FBF, 3.3+/-1.6 v 3.2+/-2.0; FVR, 35+/-14 v 37+/-15, respectively. These figures did not differ from those obtained with the auscultatory method applied to the brachial artery among 10 selected subjects studied with Finapres. In conclusion, we found no evidence that at supratherapeutic doses cyclosporine causes acute increase in blood pressure or peripheral vasoconstriction in humans.
环孢素对人体的急性血流动力学效应存在争议。我们进行了一项随机、双盲、安慰剂对照的交叉研究，以评估单次口服剂量的环孢素（20mg/kg体重）对16名健康成年受试者平均血压（MBP）、心率（HR）、前臂血流量（FBF）和血管阻力（FVR）的影响。受试者在服用环孢素或赋形剂橄榄油之前和之后各接受两次研究，中间间隔2周。在肱动脉和指动脉上测量血压。休息30分钟后，获取基础测量值，然后将个体随机分配接受环孢素或赋形剂，并在2小时后重复相同测量。单次口服环孢素2小时后，环孢素的平均全血水平为1542±387ng/mL（范围1000至2550）。与赋形剂相比，环孢素未引起血流动力学参数的任何显著变化。服用环孢素前后的数据如下（平均值±标准差）：MBP（通过指动脉上的Finapres测定），92±10对95±11mmHg；HR，66±10对68±11次/分钟；FBF，3.90±1.3对3.8±1.8mL/100mL/分钟；FVR，28±9对33±18单位。对于赋形剂，结果分别为：MBP，94±9对94±9；HR，67±9对67±11；FBF，3.3±1.6对3.2±2.0；FVR，35±14对37±15。这些数字与在使用Finapres研究的10名选定受试者中应用于肱动脉的听诊法获得的数字没有差异。总之，我们没有发现证据表明在超治疗剂量下环孢素会导致人体血压急性升高或外周血管收缩。
