精氨酸加压素对大鼠脑片从最后区到孤束核神经元相互作用的影响。

Effects of arginine-vasopressin on neuronal interaction from the area postrema to the nucleus tractus solitarii in rat brain slices.

作者信息

Migita K, Hori N, Manako J, Saito R, Takano Y, Kamiya H

机构信息

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan.

出版信息

Neurosci Lett. 1998 Oct 30;256(1):45-8. doi: 10.1016/s0304-3940(98)00753-8.

DOI:10.1016/s0304-3940(98)00753-8

PMID:9832213

Abstract

The effects of arginine-vasopressin (AVP) on area postrema (AP) neurons and the neuronal connection between the AP and nucleus tractus solitarii (NTS) were electrophysiologically investigated in rat medulla slices. In the AP, 27.9% of 129 neurons were excited by AVP and 20.5% were inhibited. The excitation was blocked by an V1 receptor antagonist. Synaptic transmission of the AP to the NTS was mainly mediated by non-N-methyl-D-aspartate (NMDA) receptors. Local application of AVP to the AP activated the NTS neurons. This excitation was also blocked by an NMDA antagonist. These results suggest that the excitation originating in the AP is conveyed to the NTS via non-NMDA receptors and then modified by NMDA receptor activation secondly. These processes may be important in the regulation of the arterial baroreceptor reflex.

摘要

在大鼠延髓切片中，用电生理学方法研究了精氨酸加压素（AVP）对最后区（AP）神经元的作用以及AP与孤束核（NTS）之间的神经元连接。在AP中，129个神经元中有27.9%被AVP兴奋，20.5%被抑制。这种兴奋被V1受体拮抗剂阻断。AP向NTS的突触传递主要由非N-甲基-D-天冬氨酸（NMDA）受体介导。向AP局部应用AVP可激活NTS神经元。这种兴奋也被NMDA拮抗剂阻断。这些结果表明，起源于AP的兴奋通过非NMDA受体传递到NTS，然后其次通过NMDA受体激活进行修饰。这些过程可能在动脉压力感受器反射的调节中起重要作用。