Miadonna A, Milazzo N, Salmaso C, Cottini M, Lorini M, Tedeschi A
Third Division of Internal Medicine, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Eur J Clin Pharmacol. 1998 Sep;54(7):515-20. doi: 10.1007/s002280050506.
N-acetyl-aspartyl-glutamic acid (NAAGA) was effective in the treatment of allergic rhinitis, with an action on early allergen-induced nasal symptoms and mediator release. The aim of this study was to evaluate the clinical activity of NAAGA and its effects on the late antigen-induced reaction in the nose.
Ten patients with allergic seasonal rhinitis were included in this randomized double-blind crossover trial of a 6% wt/vol solution of NAAGA (daily dosage 84 mg) versus placebo (lactose). The drug and placebo were administered intranasally five times daily for 1 week, with a 2-week interval between treatments.
Treatment with NAAGA, but not with placebo, significantly reduced the late antigen-induced nasal symptoms, mainly nasal obstruction. Eosinophil numbers in the nasal lavages collected 6 h and 24 h after challenge were significantly lower after NAAGA than after placebo. Active treatment also significantly reduced the neutrophil count 6 h after antigen challenge, and significantly lowered eosinophil cationic protein and myeloperoxidase levels in nasal lavages 6 h and 24 h after antigen challenge.
These results indicate that treatment for 1 week with NAAGA can reduce the late antigen-induced reaction in the nose. This is accompanied by a reduction in eosinophil and neutrophil recruitment and release of eosinophil cationic protein and myeloperoxidase.
N - 乙酰 - 天冬氨酰 - 谷氨酸（NAAGA）对过敏性鼻炎有效，可作用于早期变应原诱导的鼻部症状及介质释放。本研究旨在评估NAAGA的临床活性及其对鼻部迟发性抗原诱导反应的影响。
本随机双盲交叉试验纳入了10例季节性变应性鼻炎患者，对比6%重量/体积的NAAGA溶液（日剂量84毫克）与安慰剂（乳糖）。药物和安慰剂均经鼻给药，每日5次，持续1周，治疗间隔2周。
使用NAAGA治疗可显著减轻迟发性抗原诱导的鼻部症状，主要是鼻塞，而安慰剂则无此效果。激发后6小时和24小时采集的鼻灌洗液中的嗜酸性粒细胞数量，NAAGA治疗组显著低于安慰剂组。积极治疗还可显著降低抗原激发后6小时的中性粒细胞计数，并显著降低抗原激发后6小时和24小时鼻灌洗液中嗜酸性粒细胞阳离子蛋白和髓过氧化物酶水平。
这些结果表明，NAAGA治疗1周可减轻鼻部迟发性抗原诱导的反应。这伴随着嗜酸性粒细胞和中性粒细胞募集减少，以及嗜酸性粒细胞阳离子蛋白和髓过氧化物酶释放减少。
