通过碘苄胍单光子发射计算机断层扫描（IBZM-SPECT）测量的D2-多巴胺受体占有率与锥体外系副作用的关系。

D2-dopamine receptor occupancy measured by IBZM-SPECT in relation to extrapyramidal side effects.

作者信息

Broich K, Grünwald F, Kasper S, Klemm E, Biersack H J, Möller H J

机构信息

Klinik und Poliklinik für Psychiatrie der MLU Halle/S., Germany.

出版信息

Pharmacopsychiatry. 1998 Sep;31(5):159-62. doi: 10.1055/s-2007-979321.

DOI:10.1055/s-2007-979321

PMID:9832346

Abstract

The purpose of this study was to compare striatal D2 dopamine receptor occupancy of various typical neuroleptics and clozapine in relation to the occurrence of extrapyramidal side effects (EPS). Forty-four inpatients with schizophrenia, including 12 patients with schizodominant schizoaffective disorder, were evaluated using 123I-iodobenzamide (IBZM) and single photon emission computed tomography. Striatal D2 dopamine receptor occupancy was estimated by use of a striatal/frontal cortex ratio (ST/FC) of IBZM binding. Fourteen patients were neuroleptic-free and served as controls. Six patients were treated with clozapine and 24 patients were treated with various typical neuroleptics. ST/FC ratios in patients taking typical neuroleptics were significantly lower than those who were neuroleptic free or treated with clozapine. Patients with EPS had lower ST/FC ratios than those without EPS. A significant linear relationship between ST/FC ratios and severity of EPS estimated by the Simpson-Angus-Scale was established (r=-0.51, p=0.041).

摘要

本研究的目的是比较各种典型抗精神病药物和氯氮平的纹状体D2多巴胺受体占有率与锥体外系副作用（EPS）发生情况之间的关系。44例精神分裂症住院患者，包括12例分裂症型分裂情感性障碍患者，使用123I-碘苄胺（IBZM）和单光子发射计算机断层扫描进行评估。通过使用IBZM结合的纹状体/额叶皮质比值（ST/FC）来估计纹状体D2多巴胺受体占有率。14例未服用抗精神病药物的患者作为对照。6例患者接受氯氮平治疗，24例患者接受各种典型抗精神病药物治疗。服用典型抗精神病药物的患者的ST/FC比值显著低于未服用抗精神病药物或接受氯氮平治疗的患者。有EPS的患者的ST/FC比值低于无EPS的患者。建立了ST/FC比值与通过辛普森-安格斯量表评估的EPS严重程度之间的显著线性关系（r=-0.51，p=0.041）。