促代谢型谷氨酸受体激动剂（1S,3R-ACPD）增加老年大鼠额叶皮质多巴胺释放，但对年轻大鼠无此作用。

Metabotropic glutamate receptor agonist (1S,3R-ACPD) increased frontal cortex dopamine release in aged but not in young rats.

作者信息

Pintor A, Tiburzi F, Pezzola A, Volpe M T

机构信息

Department of Pharmacology, Istituto Superiore di Sanità, Rome, Italy.

出版信息

Eur J Pharmacol. 1998 Oct 23;359(2-3):139-42. doi: 10.1016/s0014-2999(98)00687-6.

DOI:10.1016/s0014-2999(98)00687-6

PMID:9832384

Abstract

The effects of the metabotropic glutamate (mGlu) receptor agonist (1S,3R)-1-Amino cyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) infusion on frontal cortex dopamine extracellular levels were studied by microdialysis in young (3 months) and aged (24 months) rats. Basal dopamine levels were significantly higher in young than in aged rats. (1S,3R)-ACPD (1 mM) significantly increased dopamine efflux in aged rats, an effect which was antagonized by the mGlu receptor antagonist, (S)-alpha-methyl-4-carboxypheniylglycine (MCPG) (2 mM). On the contrary, (IS,3R)-ACPD up to the concentration of 2 mM failed to influence dopamine extracellular levels in young rats. These results suggest that the agonist of mGlu receptor group I and/or II can improve dopamine release under conditions of deficiency of extracellular dopamine concentration as observed in aging.

摘要

通过微透析研究了代谢型谷氨酸（mGlu）受体激动剂（1S，3R）-1-氨基环戊烷-1,3-二羧酸（1S，3R-ACPD）注入对年轻（3个月）和老年（24个月）大鼠额叶皮质多巴胺细胞外水平的影响。年轻大鼠的基础多巴胺水平显著高于老年大鼠。（1S，3R）-ACPD（1 mM）显著增加老年大鼠的多巴胺流出，该效应被mGlu受体拮抗剂（S）-α-甲基-4-羧基苯基甘氨酸（MCPG）（2 mM）拮抗。相反，高达2 mM浓度的（1S，3R）-ACPD未能影响年轻大鼠的多巴胺细胞外水平。这些结果表明，如在衰老过程中观察到的，I组和/或II组mGlu受体激动剂可在细胞外多巴胺浓度不足的情况下改善多巴胺释放。