Nagai Y, Kemper M K, Earley C J, Metter E J
Laboratory of Clinical Investigation, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Ultrasound Med Biol. 1998 Oct;24(8):1131-6. doi: 10.1016/s0301-5629(98)00092-1.
This study defines normative flow velocity (FV) ranges for the common carotid (CCA), internal carotid (ICA) and middle cerebral arteries (MCA), compares them to subjects with nonfocal vascular disease (mild to moderate hypertension, diabetes, hyperlipidemia or coronary artery disease), and clarifies the association between carotid and MCA FVs. FVs were measured by carotid and transcranial Doppler ultrasonography in 278 healthy and 190 vascular-disease subjects. Normative FV ranges for CCA, ICA and MCA were large in healthy subjects, with modest gender and age differences. Vascular-disease subjects had similar FVs to healthy controls. MCA FVs were significantly correlated with carotid FVs (r ranged 0.26-0.50), but were only weakly or not significantly associated with them (beta ranged 0.08-0.18) when controlling for age and gender. These findings suggest that normative FVs are not affected by the presence of nonfocal vascular disease, but carotid FVs do not aid in assessing MCA FVs.
本研究定义了颈总动脉（CCA）、颈内动脉（ICA）和大脑中动脉（MCA）的正常血流速度（FV）范围，将其与患有非局灶性血管疾病（轻度至中度高血压、糖尿病、高脂血症或冠状动脉疾病）的受试者进行比较，并阐明颈动脉和MCA血流速度之间的关联。通过颈动脉和经颅多普勒超声对278名健康受试者和190名血管疾病受试者进行了血流速度测量。CCA、ICA和MCA的正常FV范围在健康受试者中较大，存在适度的性别和年龄差异。血管疾病受试者的血流速度与健康对照者相似。MCA血流速度与颈动脉血流速度显著相关（r范围为0.26 - 0.50），但在控制年龄和性别后，与它们的关联仅较弱或无显著关联（β范围为0.08 - 0.18）。这些发现表明，正常FV不受非局灶性血管疾病的影响，但颈动脉血流速度无助于评估MCA血流速度。
