Suzuki S, Morishita S
College of Medical Technology, Hokkaido University, Sapporo, Japan.
Semin Thromb Hemost. 1998;24(5):449-51. doi: 10.1055/s-2007-996038.
Platelet hemostatic capacity (PHC) was measured in blood from pregnant patients during all three trimesters using the PFA-100 system. Closure times were shorter with both cartridge systems during pregnancy, compared to non-pregnant controls, suggesting increased PHC. Thrombin/antithrombin (TAT) complex and prothrombin fragment 1 + 2 (F 1+2) levels were elevated during pregnancy and increased over time. Also, plasma levels of plasminogen activator inhibitor 1 and 2 (PAI-1, PAI-2) increased during pregnancy. The data suggest increased coagulability during pregnancy. It is suggested that estrogen may play a role in this state of hypercoagulability. Seven days after delivery all of the measured parameters, except TAT levels, were again within normal range.
使用PFA-100系统对孕期三个阶段孕妇的血液进行血小板止血能力（PHC）检测。与非孕对照组相比，孕期使用两种检测卡系统测得的封闭时间均较短，提示血小板止血能力增强。孕期凝血酶/抗凝血酶（TAT）复合物及凝血酶原片段1 + 2（F 1+2）水平升高，且随时间增加。此外，孕期血浆纤溶酶原激活物抑制剂1和2（PAI-1、PAI-2）水平也升高。这些数据提示孕期血液凝固性增加。有观点认为雌激素可能在这种高凝状态中起作用。分娩7天后，除TAT水平外，所有检测参数均恢复至正常范围。
