Lee K K, Bahler B D, Hofmann G A, Mattern M R, Johnson R K, Kingston D G
Department of Chemistry, Virginia Polytechnic and State University, Blacksburg, Virginia 24061-0212, USA.
J Nat Prod. 1998 Nov;61(11):1407-9. doi: 10.1021/np9801460.
Bioassay-guided fractionation of the CH2Cl2-MeOH extract of Pinus flexilis using an assay for protein kinase C (PKC) inhibitory activity led to the isolation of the two new bioactive diarylheptanoids (3R)-1,7-bis(3, 4-dihydroxyphenyl)-3-(beta-D-glucopyranosyl)heptan-3-ol (1) and its aglycon (3R)-1,7-bis(3,4-dihydroxyphenyl)heptan-3-ol (2), together with the three known bioactive compounds, hirsutenone (3), oregonin (4), and hirsutanonol (5). The IC50 values of compounds 1-5 in the PKC assay were 1.4, 1.6, 1.4, 8.6, and 4.6 microg/mL, respectively.
