Abram F, Linke F, Kalfon A, Tchovelidze C, Chelbi N, Arvis G
Service d'Uro-Andrologie, Hôpital Tenon, Paris, France.
Prog Urol. 1998 Sep;8(4):537-41.
Hyperprolactinemia is the cause of erectile dysfunction in less than 1% of cases. From 1989 to 1996, 13 patients consulted for erectile disorders associated with hyperprolactinemia. The mean age was 47.5 years. 10 patients complained of decreased libido. 3 patients had gynecomastia. Plasma prolactin levels ranged from 31.3 ng/ml to 1,300 ng/ml. 7 patients had a plasma testosterone less than 4 ml/ng. 7 patients had a micro- or macroadenoma of the sella turcica visualized by MRI. After drug treatment, plasma prolactin levels returned to normal in all patients in whom assays were performed. 6 patients considered that their erectile function was restored. 5 of the 6 patients with no improvement of their sexual function had a concomitant disease able to explain the impotence. Hyperprolactinemia is a rare cause of erectile dysfunction, but it must be considered in any patient presenting with idiopathic erectile dysfunction associated with decreased libido, gynecomastia, and decreased plasma testosterone. Drug treatment is effective and MRI of the sella turcica should be performed looking for a pituitary adenoma.
高催乳素血症是不到1%的勃起功能障碍病例的病因。1989年至1996年,有13例因与高催乳素血症相关的勃起功能障碍前来咨询的患者。平均年龄为47.5岁。10例患者主诉性欲减退。3例患者有男性乳房发育。血浆催乳素水平在31.3 ng/ml至1300 ng/ml之间。7例患者血浆睾酮低于4 ml/ng。7例患者经MRI检查发现蝶鞍有微腺瘤或大腺瘤。药物治疗后,所有接受检测的患者血浆催乳素水平均恢复正常。6例患者认为其勃起功能得到恢复。6例性功能未改善的患者中有5例患有其他疾病,这些疾病可以解释其阳痿症状。高催乳素血症是勃起功能障碍的罕见病因,但对于任何出现与性欲减退、男性乳房发育和血浆睾酮降低相关的特发性勃起功能障碍的患者,都必须考虑到这一病因。药物治疗有效,应进行蝶鞍MRI检查以寻找垂体腺瘤。