Hannequin D, Campion D, Dumanchin C, Martinez M, Agid Y, Clerget-Darpoux F, Frebourg T, Brice A
Fédération de Neurologie, CHU, Rouen.
Rev Neurol (Paris). 1998;154 Suppl 2:S65-74.
This review reports epidemiological data and biological mechanisms about the Apolipoprotein E gene allele epsilon 4 that is a major risk factor for Alzheimer's disease (AD). The second part describes the three genes, amyloid precusor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) genes, which when mutated cause early-onset autosomal dominant AD. Mutations on each of these genes have as a common consequence elevated levels of A beta (42,3).
本综述报告了载脂蛋白E基因ε4等位基因的流行病学数据和生物学机制，该等位基因是阿尔茨海默病（AD）的主要危险因素。第二部分描述了三个基因，即淀粉样前体蛋白（APP）基因、早老素1（PS1）基因和早老素2（PS2）基因，这些基因发生突变时会导致早发性常染色体显性AD。这些基因中的每一个发生突变的共同后果是β淀粉样蛋白（Aβ，42,3）水平升高。
