Yamaguchi S, Yanagita S, Wake K, Mishio M, Okuda Y, Kitajima T
First Department of Anesthesiology, Dokkyo University School of Medicine, Tochigi.
Masui. 1998 Oct;47(10):1240-2.
A 59-year-old male with hypertrophic cardiomyopathy was scheduled for resection of a maxillary cyst. Metoprolol was discontinued the day before surgery. Thirty min before anesthesia, meperidine 35 mg was administered intramuscularly. After intravenous administration of midazolam 3 mg, a pulmonary catheter was inserted for monitoring hemodynamic parameters. Anesthesia was induced with propofol 75 mg, fentanyl 0.15 mg and ketamine 75 mg. Anesthesia was maintained with continuous infusion of propofol 5 mg.kg-1.h-1 and ketamine 1 mg.kg-1.h-1. Moreover, fentanyl was added as necessary during surgery. Blood pressure (BP), pulmonary arterial pressure (PA), systemic vascular resistance index (SVRI) and pulmonary vascular resistance index (PVRI) were measured using a pulmonary catheter during anesthesia. Since BP decreased after intubation, dopamine 3 micrograms.kg-1.min-1 was administered for 20 min. The hemodynamic state was stable during surgery. However, BP, PA, SVRI and PVRI increased temporally at extubation. His postoperative course was uneventful. In conclusion, total intravenous anesthesia with propofol, fentanyl and ketamine may be useful for anesthetic management of a patient with hypertrophic cardiomyopathy.
一名59岁的肥厚型心肌病男性患者计划接受上颌囊肿切除术。术前一天停用美托洛尔。麻醉前30分钟,肌内注射哌替啶35毫克。静脉注射咪达唑仑3毫克后,插入肺动脉导管以监测血流动力学参数。采用丙泊酚75毫克、芬太尼0.15毫克和氯胺酮75毫克诱导麻醉。通过持续输注丙泊酚5毫克·千克⁻¹·小时⁻¹和氯胺酮1毫克·千克⁻¹·小时⁻¹维持麻醉。此外,手术期间必要时添加芬太尼。麻醉期间使用肺动脉导管测量血压(BP)、肺动脉压(PA)、全身血管阻力指数(SVRI)和肺血管阻力指数(PVRI)。由于插管后血压下降,给予多巴胺3微克·千克⁻¹·分钟⁻¹,持续20分钟。手术期间血流动力学状态稳定。然而,拔管时血压、肺动脉压、全身血管阻力指数和肺血管阻力指数暂时升高。他的术后过程顺利。总之,丙泊酚、芬太尼和氯胺酮全静脉麻醉可能有助于肥厚型心肌病患者的麻醉管理。