Enhancement of diltiazem bioavailability by traces of surfactants in rats after neomycin-induced malabsorption syndrome.
作者信息
Wojdak H
机构信息
Department of Applied Pharmacy and Drug Design Technology, Medical Academy of Silesia, Sosnowiec, Poland.
出版信息
Boll Chim Farm. 1998 Sep;137(8):314-8.
PMID:9835146
Abstract
Bioavailability of diltiazem was investigated in rats with the neomycin induced malabsorption syndrome in presence of surfactants. Tween 80, sodium lauroyl sulphate and lecithin were added under their critical miscellar concentration levels. Increases of diltiazem bioavailability (in the range of 5-29%) promoted by additions of the surfactants were observed.
摘要
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