Wojdak H
Department of Applied Pharmacy and Drug Design Technology, Medical Academy of Silesia, Sosnowiec, Poland.
Boll Chim Farm. 1998 Sep;137(8):314-8.
Bioavailability of diltiazem was investigated in rats with the neomycin induced malabsorption syndrome in presence of surfactants. Tween 80, sodium lauroyl sulphate and lecithin were added under their critical miscellar concentration levels. Increases of diltiazem bioavailability (in the range of 5-29%) promoted by additions of the surfactants were observed.
在存在表面活性剂的情况下，研究了地尔硫䓬在新霉素诱导的吸收不良综合征大鼠中的生物利用度。在临界胶束浓度水平以下添加吐温80、月桂醇硫酸酯钠和卵磷脂。观察到添加表面活性剂可促进地尔硫䓬生物利用度的提高（提高范围为5%-29%）。
