3-[N'-磺胺多辛亚氨基]异吲哚酮及其甲基衍生物的N-曼尼希碱的合成与抗菌活性
Synthesis and antimicrobial activity of N-Mannich bases of 3-[N'-sulphadoximino] isatin and its methyl derivative.
作者信息
Pandeya N, Yogeeswari P, Ram D S, Nath G
机构信息
Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
出版信息
Boll Chim Farm. 1998 Sep;137(8):321-4.
PMID:9835147
Abstract
Schiff's bases of isatin and 5-methyl isatin with sulphadoxine and then its N-Mannich bases were synthesised and evaluated for their anti-microbial activity. The piperidonemethyl group improved the activity and most of the compounds were more potent than the pure drugs.
摘要
合成了异吲哚酮和5-甲基异吲哚酮与磺胺多辛的席夫碱，然后合成了它们的N-曼尼希碱，并对其抗菌活性进行了评估。哌啶甲基增强了活性，大多数化合物比纯药物更有效。
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