向中脑导水管周围灰质投射的I层神经元数量是向丘脑投射的三倍：猫的逆行追踪研究。

Three times as many lamina I neurons project to the periaqueductal gray than to the thalamus: a retrograde tracing study in the cat.

作者信息

Mouton L J, Holstege G

机构信息

Department of Anatomy and Embryology, Faculty of Medical Sciences, Rijksuniversiteit Groningen, The Netherlands.

出版信息

Neurosci Lett. 1998 Oct 16;255(2):107-10. doi: 10.1016/s0304-3940(98)00723-x.

DOI:10.1016/s0304-3940(98)00723-x

PMID:9835226

Abstract

The number and distribution of lamina I neurons projecting to the periaqueductal gray (PAG) were examined by a retrograde tracing study in the cat. WGA-HRP injections in the intermediate and caudal PAG resulted in as much as 1600 labeled lamina I neurons throughout the length of the spinal cord, counted in a 1:4 series of sections. The lamina I-PAG projection was predominantly contralateral and most labeled lamina I neurons were found in the enlargements. Comparing these results with the number of lamina I-thalamic neurons leads to the conclusion that in the cat about three times as many lamina I neurons project to the PAG than to the thalamus. Considering this, one can conclude that the spino-PAG system is a virtually neglected area in pain research.

摘要

通过在猫身上进行的逆行追踪研究，检测了投射到导水管周围灰质（PAG）的I层神经元的数量和分布。在中脑导水管周围灰质的中部和尾部注射WGA-HRP，在脊髓全长范围内，按1:4的切片系列计数，多达1600个I层神经元被标记。I层至PAG的投射主要是对侧的，且大多数被标记的I层神经元见于脊髓膨大处。将这些结果与I层至丘脑的神经元数量进行比较后得出结论，在猫中，投射到PAG的I层神经元数量约为投射到丘脑的三倍。考虑到这一点，可以得出结论，脊髓-导水管周围灰质系统在疼痛研究中实际上是一个被忽视的领域。