Nickel W, Brügger B, Wieland F T
Cellular Biochemistry and Biophysics Program, Rockefeller Research Laboratories, Memorial Sloan Kettering Cancer Center, New York, NY, 10021, USA.
Semin Cell Dev Biol. 1998 Oct;9(5):493-501. doi: 10.1006/scdb.1998.0256.
Vesicular traffic within the early secretory pathway is mediated by COPI- and COPII-coated vesicles. While COPII-coated vesicles appear to be involved exclusively in the export of secretory proteins and lipids from the endoplasmic reticulum (ER), COPI-coated vesicles seem to function in both anterograde and retrograde transport between the ER-Golgi intermediate compartment (IC) and the Golgi as well as in intra-Golgi transport. Here, we focus on (i) the mechanisms how these transport carriers are formed from a given donor membrane; and (ii) the possible mechanisms involved in sorting of proteins and lipids into such transport vesicles.
早期分泌途径中的囊泡运输由COP I包被囊泡和COP II包被囊泡介导。虽然COP II包被囊泡似乎仅参与从内质网（ER）输出分泌蛋白和脂质，但COP I包被囊泡似乎在内质网-高尔基体中间区室（IC）与高尔基体之间的顺行和逆行运输以及高尔基体内部运输中发挥作用。在这里，我们关注：（i）这些运输载体如何从给定的供体膜形成的机制；以及（ii）蛋白质和脂质分选到此类运输囊泡中可能涉及的机制。
