Thiele C, Huttner W B
Max-Planck-Institute of Molecular Cell Biology and Genetics, Im Neuenheimer Feld 364, Heidelberg, D-69120, Germany.
Semin Cell Dev Biol. 1998 Oct;9(5):511-6. doi: 10.1006/scdb.1998.0259.
Secretory granules are the cellular organelles mediating storage and regulated secretion of proteins. Their biogenesis involves sorting of secretory protein cargo and membrane constituents, which takes place at two distinct levels, the trans-Golgi network and the immature secretory granule. At both levels, sorting is accomplished by cargo aggregation and cargo-membrane recognition. Given not only the aggregative properties of the regulated secretory proteins but also the ability of lipids to form distinct membrane microdomains, self-organization of both lumenal and membrane constituents is proposed to play a crucial role in secretory granule biogenesis.
分泌颗粒是介导蛋白质储存和调节性分泌的细胞器。它们的生物发生涉及分泌蛋白货物和膜成分的分选，这发生在两个不同的水平，即反式高尔基体网络和未成熟分泌颗粒。在这两个水平上，分选都是通过货物聚集和货物-膜识别来完成的。鉴于调节性分泌蛋白的聚集特性以及脂质形成不同膜微区的能力，腔内和膜成分的自组织被认为在分泌颗粒的生物发生中起关键作用。
