Berthier S, Toussirot E, Wendling D
Service de Rhumatologie, Hôpital Jean Minjoz, CHU, Besançon.
Presse Med. 1998 Nov 7;27(34):1718-22.
The position of remitting seronegative symmetrical synovitis with pitting edema (RS3PE syndrome) among inflammatory rheumatic diseases. Is it a distinct syndrome or a clinical feature?
To answer this question a retrospective study was conducted in 13 elderly patients (mean age: 72 years). The clinical course and laboratory findings were followed for 3 to 172 months after disease onset.
In two patients, another disease was diagnosed: polymyalgia rheumatica, late onset peripheral spondylarthropathy. Two relapses of RS3PE were noted. There was no clinical difference between initial RS3PE and relapsing RS3PE. In four cases, RS2PE syndrome revealed another disease: dermatopolymyositis, AL amyloidosis, polymyalgia rheumatica, late onset peripheral spondylarthropathy. No rheumatoid arthritis appeared, but one patient was positive for rheumatoid factors. A benign course was observed in all patients, without paraneoplastic syndrome and without death.
Benign edematous polyarthritis in the elderly is a syndrome that may reveal connective tissue disease or inflammatory rheumatic disease.
缓解性血清阴性对称性滑膜炎伴凹陷性水肿（RS3PE综合征）在炎性风湿性疾病中的地位。它是一种独特的综合征还是一种临床特征？
为回答这个问题，对13例老年患者（平均年龄：72岁）进行了一项回顾性研究。在疾病发作后3至172个月对临床病程和实验室检查结果进行了随访。
2例患者诊断出其他疾病：风湿性多肌痛、迟发性外周脊柱关节病。记录到2例RS3PE复发。初发RS3PE与复发RS3PE之间无临床差异。4例RS2PE综合征患者显示出其他疾病：皮肌炎、AL淀粉样变性、风湿性多肌痛、迟发性外周脊柱关节病。未出现类风湿关节炎，但1例患者类风湿因子呈阳性。所有患者病程良性，无副肿瘤综合征且无死亡。
老年人良性水肿性多关节炎是一种可能提示结缔组织病或炎性风湿性疾病的综合征。
