Folle L E, Levesque R I
Acta Biol Med Ger. 1976;35(5):605-12.
The effects of several anesthetics on some cardiovascular, respiratory and metabolic responses were studied in the rat. Drugs were given by the intraperitoneal route and observations were made during a period of three hours after the injection of the agent. Results were compared with normal values obtained from unanesthetized animals. The most striking findings were: urethane produced a metabolic acidosis; chloralose increased heart rate, morphine-chloralose mixture produced a sustained hypoxia. None of these agents evoked arrhythmias in the rat. Effects of the anesthesia should be taken into account in the evaluation of drugs in anesthetized rats.
研究了几种麻醉剂对大鼠某些心血管、呼吸和代谢反应的影响。通过腹腔注射给药，并在注射药物后的三小时内进行观察。将结果与未麻醉动物的正常值进行比较。最显著的发现是：乌拉坦导致代谢性酸中毒；氯醛糖增加心率，吗啡-氯醛糖混合物导致持续性缺氧。这些药物在大鼠中均未诱发心律失常。在评估麻醉大鼠中的药物时，应考虑麻醉的影响。
