Fusek J, Patocka J
Acta Biol Med Ger. 1976;35(5):657-61.
The effect of eight monoquaternary and bisquaternary pyridine aldoxime cholinesterase reactivators was tested on isolated guinea-pig heart atria. 2. Acetylcholine and methylfurthretonium in concentrations ranging from 10(-7) M to 10(-5) M have negative inotropic effects in the electrically stimulated atria and negative chronotropic effects in the spontaneously beating atria. 3. In the presence of higher concentration of cholinesterase reactivators alone, the parameters of heart muscle contractility are significantly altered. 4. Cumulative dose-response curves of methylfurthretonium in the presence of reactivators in the range of concentrations from 10(-5) M to 10(-3) M are shifted parallelly to higher concentrations of the agonist.
测试了八种单季铵和双季铵吡啶肟胆碱酯酶重活化剂对离体豚鼠心房的作用。
浓度范围为10⁻⁷ M至10⁻⁵ M的乙酰胆碱和甲基呋喃托铵对电刺激的心房有负性肌力作用，对自发搏动的心房有负性变时作用。
单独存在较高浓度的胆碱酯酶重活化剂时，心肌收缩性参数会发生显著改变。
在浓度范围为10⁻⁵ M至10⁻³ M的重活化剂存在下，甲基呋喃托铵的累积剂量 - 反应曲线平行地向更高浓度的激动剂方向移动。
