一种天然α1-酸性糖蛋白及其连接到无蛋白聚合物上的糖链的免疫调节活性。
Immunomodulating activities of a natural alpha1-acid glycoprotein and its carbohydrate chains attached to the protein-free polymer.
作者信息
Pukhalsky A L, Shyian S D, Kalashnikova E A, Shmarina G V, Pukhalskaya D A, Bovin N V
机构信息
Research Centre for Medical Genetics, Moscow, Russia.
出版信息
Mediators Inflamm. 1998;7(2):115-8. doi: 10.1080/09629359891270.
Immunomodulating effects of a neoglycoconjugate created on the basis of alpha1-acid glycoprotein (AGP) carbohydrate chains and synthetic protein-free carrier have been investigated. It was demonstrated that this pseudo-AGP suppressed PHA- or anti-CD3 antibody-induced lymphocyte proliferation in a dose-dependent manner. Pseudo-AGP revealed a similar antiproliferative effect as the natural AGP samples. Stimulation of the LPS-induced proinflammatory cytokine production by mononuclear cells treated with both natural and pseudo-AGP has been also demonstrated. These data show that carbohydrate chains of AGP play a crucial role in the studied biological effect realization.
对基于α1-酸性糖蛋白（AGP）糖链和无蛋白合成载体构建的新糖缀合物的免疫调节作用进行了研究。结果表明，这种假AGP以剂量依赖的方式抑制PHA或抗CD3抗体诱导的淋巴细胞增殖。假AGP显示出与天然AGP样品相似的抗增殖作用。还证实了天然和假AGP处理的单核细胞对LPS诱导的促炎细胞因子产生的刺激作用。这些数据表明，AGP的糖链在所研究的生物学效应实现中起关键作用。
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