Wang H S, Pan Z, Shi W, Brown B S, Wymore R S, Cohen I S, Dixon J E, McKinnon D
Institute of Molecular Cardiology, Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.
Science. 1998 Dec 4;282(5395):1890-3. doi: 10.1126/science.282.5395.1890.
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.
M电流调节许多神经元的阈下电兴奋性，决定其放电特性和对突触输入的反应性。然而，迄今为止，编码这一重要通道亚基的基因尚未被鉴定出来。研究确定了KCNQ2和KCNQ3钾通道的生物物理特性、对药理学阻断的敏感性及表达模式。得出的结论是，这两个亚基均对天然M电流有贡献。
