Loh K, Matthay K K, Hoover M, Bracho F A, Cortez A B, Conte F A, Albanese C T, Miller T R, Price D C, Flores A J, Kaviani A, Shoback D
Division of Endocrinology and Metabolism, University of California, San Francisco, Calif., USA.
Horm Res. 1998;50(4):217-21. doi: 10.1159/000023277.
A 15-year-old boy had hypercalcemia in association with malignant retroperitoneal paraganglioma. He had suppressed circulating levels of intact parathyroid hormone, whereas parathyroid hormone-related protein (PTHrP) immunoreactivity was elevated in plasma. Both the serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels were normal. Preoperatively the patient required control of hypercalcemia with intravenous pamidronate therapy. His circulating calcium and PTHrP concentrations became normal after a successful surgical resection of the primary retroperitoneal tumor. To our knowledge, this is the first reported case of elevated PtHrP levels in a patient with paraganglioma which resolved postoperatively.
一名15岁男孩患有高钙血症，伴有恶性腹膜后副神经节瘤。他的循环中完整甲状旁腺激素水平受到抑制，而血浆中甲状旁腺激素相关蛋白（PTHrP）免疫反应性升高。血清25-羟维生素D和1,25-二羟维生素D水平均正常。术前患者需要通过静脉注射帕米膦酸治疗来控制高钙血症。在成功手术切除原发性腹膜后肿瘤后，他的循环钙和PTHrP浓度恢复正常。据我们所知，这是首例报道的副神经节瘤患者PTHrP水平升高且术后恢复正常的病例。
