Watanabe Y, Sato M, Abe Y, Yamamoto T, Kashu Y, Horiuchi A, Hamada Y, Nakata T, Lee T, Kawachi K
Second Department of Surgery, Ehime University, Shigenobu, Japan.
Transplant Proc. 1998 Nov;30(7):3777-8. doi: 10.1016/s0041-1345(98)01233-0.
This perfusion model enables a pharmacokinetic study of enteral absorption and hepatic metabolic rate simultaneously. FK 506 is absorbed mainly via the proximal small intestine and metabolized rapidly by the liver during single passage. These results may lead to further analyses of absorption and metabolism of FK 506 under various conditions.
该灌注模型能够同时对肠内吸收和肝脏代谢率进行药代动力学研究。FK 506主要通过近端小肠吸收，并在单次通过肝脏时迅速代谢。这些结果可能会促使人们进一步分析在各种条件下FK 506的吸收和代谢情况。
