Toi M
Dept. of Surgery, Tokyo Metropolitan Komagome Hospital, Japan.
Gan To Kagaku Ryoho. 1998 Nov;25(13):2003-9.
Tumor vasculature is a promising novel target for anticancer treatment. Natural or synthetic products have been developed, and endogenous inhibitors such as angiostatin have been extensively analyzed. Several inhibitors are currently under investigation, and many compounds are tested in pre-clinical trials. This review provides an overview of the antiangiogenic treatments as well as early clinical result with these agents.
肿瘤血管系统是抗癌治疗中一个很有前景的新靶点。天然或合成产物已被研发出来，诸如血管抑素等内源性抑制剂也已得到广泛分析。目前有几种抑制剂正在研究中，许多化合物正在进行临床前试验。本综述概述了抗血管生成治疗以及这些药物的早期临床结果。
