Psarianos T, Kench J G, Ung O A, Bilous A M
Department of Tissue Pathology, Westmead Hospital, New South Wales, Australia.
Pathology. 1998 Nov;30(4):419-21. doi: 10.1080/00313029800169736.
We describe a case of ductal carcinoma in situ (DCIS) occurring in a fibroadenoma diagnosed by fine needle aspiration (FNA) cytology. The cytological features comprised a small population of pleomorphic cells admixed with a dominant population of bland epithelial cells showing features consistent with those of a fibroadenoma. Excision biopsy confirmed the presence of DCIS within an otherwise typical fibroadenoma. Recent reviews have emphasised the potential for fibroadenoma to cytologically mimic carcinoma, leading to false positive findings, however the converse is also possible. We conclude that a false negative cytological diagnosis may be avoided by recommending histological confirmation by excision biopsy when significant atypia is present, even if the overall pattern is that of a fibroadenoma.
我们描述了一例通过细针穿刺（FNA）细胞学诊断为纤维腺瘤内发生导管原位癌（DCIS）的病例。细胞学特征包括少量多形性细胞与大量形态温和的上皮细胞混合，后者表现出与纤维腺瘤一致的特征。切除活检证实了在一个原本典型的纤维腺瘤内存在DCIS。近期的综述强调了纤维腺瘤在细胞学上可能模拟癌，导致假阳性结果，然而反之亦有可能。我们得出结论，当存在显著异型性时，即使总体形态为纤维腺瘤，通过推荐切除活检进行组织学确认，可避免假阴性细胞学诊断。
