Graham J M, Edwards M J, Edwards M J
Medical Genetics Birth Defects Center, UCLA School of Medicine, Cedars-Sinai Medical Center, USA.
Teratology. 1998 Nov;58(5):209-21. doi: 10.1002/(SICI)1096-9926(199811)58:5<209::AID-TERA8>3.0.CO;2-Q.
This review has covered the pertinent literature concerning the teratogenic effects of hyperthermia in man and experimental animals. This is the first teratogen that was initially discovered in animals and then subsequently found to be a cause for concern in humans when similar patterns of defects were observed. Hyperthermia is a physical agent with a dose-response curve for abortions and malformations, but these effects can be mitigated in some circumstances by the heat shock response (HSR). We have reviewed the known functions of HSR and provided some insight into why embryos have some protection following an initial dose of heat, if it is sufficient to initiate the response. Thus, by reviewing the effects of hyperthermia in experimental animals, as well as malformative and protective mechanisms of teratogenesis, we have attempted to understand the effects of human hyperthermia teratogenesis.
本综述涵盖了有关高温对人类和实验动物致畸作用的相关文献。这是第一种最初在动物身上发现，随后当观察到类似的缺陷模式时，人们发现它也会引起人类关注的致畸原。高温是一种具有导致流产和畸形的剂量反应曲线的物理因素，但在某些情况下，热休克反应（HSR）可以减轻这些影响。我们回顾了热休克反应的已知功能，并对为什么胚胎在初次接受足以引发该反应的热剂量后会有一定保护作用提供了一些见解。因此，通过回顾高温在实验动物中的影响以及致畸的畸形形成和保护机制，我们试图了解人类高温致畸的影响。
