Saito K, Koizumi K, Abe K, Goto Y, Seki T
Department of Radiology, Musashino Red Cross Hospital, Tokyo, Japan.
Ann Nucl Med. 1998 Oct;12(5):275-80. doi: 10.1007/BF03164913.
To evaluate the effect of technetium-99m-labeled DTPA-galactosyl human serum albumin (Tc-99m-GSA) SPECT imaging for qualitative diagnosis of hepatic lesions. The subjects were 29 patients with pathologically confirmed hepatic lesions (21 malignant and 8 benign lesions). SPECT data were obtained at about 30 minutes after injecting 185 MBq (5 mCi) of Tc-99m-GSA. The GSA SPECT findings were compared with those of pathological evaluation and T2-weighted MR images (T2WI). Of 29 lesions, 17 showed decreased accumulation, and three exhibited increased accumulation. The other nine lesions were undetectable. The malignant lesions which showed increased accumulation were all well differentiated hepatocellular carcinomas (HCCs). One of the eight benign lesions exhibited increased accumulation. The three lesions which showed increased accumulation of GSA exhibited hypointensity on T2WI, whereas the malignant lesions which showed decreased accumulation of GSA exhibited hyperintensity on T2WI. The GSA SPECT findings correlate well with those of T2WI. GSA SPECT may be useful for qualitative diagnosis of focal liver lesions. If a lesion is suspected of being HCC, increased accumulation may indicate well differentiated HCC.
评估锝-99m标记的二乙三胺五乙酸-半乳糖基人血清白蛋白（Tc-99m-GSA）单光子发射计算机断层显像（SPECT）对肝脏病变定性诊断的效果。研究对象为29例经病理证实的肝脏病变患者（21例恶性病变和8例良性病变）。在注射185 MBq（5 mCi）的Tc-99m-GSA后约30分钟获取SPECT数据。将GSA SPECT检查结果与病理评估结果及T2加权磁共振成像（T2WI）结果进行比较。29个病变中，17个表现为放射性摄取减低，3个表现为放射性摄取增加。另外9个病变未显示。放射性摄取增加的恶性病变均为高分化肝细胞癌（HCC）。8个良性病变中有1个表现为放射性摄取增加。GSA放射性摄取增加的3个病变在T2WI上呈低信号，而GSA放射性摄取减低的恶性病变在T2WI上呈高信号。GSA SPECT检查结果与T2WI结果具有良好的相关性。GSA SPECT可能有助于肝脏局灶性病变的定性诊断。如果怀疑病变为HCC，放射性摄取增加可能提示高分化HCC。
